25441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 707643..708268 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MAF_RS03230 Protein ID WP_003403218.1
Coordinates 707867..708268 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MAF_RS03225 Protein ID WP_003403213.1
Coordinates 707643..707870 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS03195 702822..703043 - 222 WP_031666828.1 DUF4926 domain-containing protein -
MAF_RS03200 703185..703790 + 606 WP_003898526.1 hypothetical protein -
MAF_RS03205 703809..706376 - 2568 WP_003900188.1 SEC-C domain-containing protein -
MAF_RS03210 706460..707209 + 750 WP_003898528.1 hypothetical protein -
MAF_RS03215 707206..707448 + 243 WP_003403210.1 hypothetical protein -
MAF_RS03225 707643..707870 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MAF_RS03230 707867..708268 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MAF_RS22110 708397..708480 + 84 Protein_639 galactose-1-phosphate uridylyltransferase -
MAF_RS03235 708499..709581 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
MAF_RS03240 709578..710663 + 1086 WP_003910166.1 galactokinase -
MAF_RS03250 711058..712215 + 1158 WP_003903091.1 hypothetical protein -
MAF_RS03255 712226..713173 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T25441 WP_003403218.1 NC_015758:707867-708268 [Mycobacterium tuberculosis variant africanum GM041182]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T25441 NC_015758:707867-708268 [Mycobacterium tuberculosis variant africanum GM041182]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT25441 WP_003403213.1 NC_015758:707643-707870 [Mycobacterium tuberculosis variant africanum GM041182]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT25441 NC_015758:707643-707870 [Mycobacterium tuberculosis variant africanum GM041182]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References