Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4710671..4711187 Replicon chromosome
Accession NZ_CP102889
Organism Klebsiella pneumoniae strain KW2

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag NWT79_RS22925 Protein ID WP_009486548.1
Coordinates 4710671..4710955 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NWT79_RS22930 Protein ID WP_002886901.1
Coordinates 4710945..4711187 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT79_RS22900 (NWT79_22900) 4706088..4706351 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NWT79_RS22905 (NWT79_22905) 4706481..4706654 + 174 WP_002886906.1 hypothetical protein -
NWT79_RS22910 (NWT79_22910) 4706657..4707400 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NWT79_RS22915 (NWT79_22915) 4707757..4709895 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NWT79_RS22920 (NWT79_22920) 4710203..4710667 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NWT79_RS22925 (NWT79_22925) 4710671..4710955 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT79_RS22930 (NWT79_22930) 4710945..4711187 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NWT79_RS22935 (NWT79_22935) 4711265..4713175 - 1911 WP_023288161.1 PRD domain-containing protein -
NWT79_RS22940 (NWT79_22940) 4713198..4714352 - 1155 WP_002886900.1 lactonase family protein -
NWT79_RS22945 (NWT79_22945) 4714419..4715159 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T254400 WP_009486548.1 NZ_CP102889:c4710955-4710671 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254400 WP_002886901.1 NZ_CP102889:c4711187-4710945 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References