Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2643278..2644866 Replicon chromosome
Accession NZ_CP102889
Organism Klebsiella pneumoniae strain KW2

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag NWT79_RS12950 Protein ID WP_004190166.1
Coordinates 2643278..2644600 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NWT79_RS12955 Protein ID WP_002904790.1
Coordinates 2644600..2644866 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT79_RS12935 (NWT79_12935) 2638334..2640835 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
NWT79_RS12940 (NWT79_12940) 2640823..2641827 + 1005 WP_004190163.1 fimbrial protein -
NWT79_RS12945 (NWT79_12945) 2641969..2643261 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NWT79_RS12950 (NWT79_12950) 2643278..2644600 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
NWT79_RS12955 (NWT79_12955) 2644600..2644866 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NWT79_RS12960 (NWT79_12960) 2645131..2645457 - 327 WP_004143476.1 hydroxyisourate hydrolase -
NWT79_RS12965 (NWT79_12965) 2645454..2645954 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NWT79_RS12970 (NWT79_12970) 2645932..2647311 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
NWT79_RS12975 (NWT79_12975) 2647657..2648811 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NWT79_RS12980 (NWT79_12980) 2648792..2649715 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T254397 WP_004190166.1 NZ_CP102889:c2644600-2643278 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254397 WP_002904790.1 NZ_CP102889:c2644866-2644600 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References