Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802434..803091 Replicon chromosome
Accession NZ_CP102889
Organism Klebsiella pneumoniae strain KW2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NWT79_RS03975 Protein ID WP_002916310.1
Coordinates 802681..803091 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NWT79_RS03970 Protein ID WP_002916312.1
Coordinates 802434..802700 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT79_RS03945 (NWT79_03945) 797590..799023 - 1434 WP_128306618.1 6-phospho-beta-glucosidase BglA -
NWT79_RS03950 (NWT79_03950) 799142..799870 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NWT79_RS03955 (NWT79_03955) 799920..800231 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NWT79_RS03960 (NWT79_03960) 800395..801054 + 660 WP_002916317.1 hemolysin III family protein -
NWT79_RS03965 (NWT79_03965) 801205..802188 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NWT79_RS03970 (NWT79_03970) 802434..802700 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NWT79_RS03975 (NWT79_03975) 802681..803091 + 411 WP_002916310.1 protein YgfX Toxin
NWT79_RS03980 (NWT79_03980) 803098..803619 - 522 WP_002916308.1 flavodoxin FldB -
NWT79_RS03985 (NWT79_03985) 803720..804616 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NWT79_RS03990 (NWT79_03990) 804639..805352 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWT79_RS03995 (NWT79_03995) 805358..807091 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254392 WP_002916310.1 NZ_CP102889:802681-803091 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254392 WP_002916312.1 NZ_CP102889:802434-802700 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References