Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 89747..90498 Replicon plasmid pKH2-1
Accession NZ_CP102884
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag M2890_RS26625 Protein ID WP_014386536.1
Coordinates 89747..90229 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag M2890_RS26630 Protein ID WP_004902250.1
Coordinates 90220..90498 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS26605 (M2890_26605) 86146..86793 - 648 WP_014386537.1 EcsC family protein -
M2890_RS26610 (M2890_26610) 86820..87575 - 756 WP_004902235.1 DUF2971 domain-containing protein -
M2890_RS26615 (M2890_26615) 87676..88068 - 393 WP_032442757.1 hypothetical protein -
M2890_RS26620 (M2890_26620) 88173..88712 - 540 WP_004902239.1 hypothetical protein -
M2890_RS26625 (M2890_26625) 89747..90229 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
M2890_RS26630 (M2890_26630) 90220..90498 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
M2890_RS26635 (M2890_26635) 90617..90829 - 213 WP_004902255.1 hypothetical protein -
M2890_RS26640 (M2890_26640) 90937..91278 - 342 WP_004902257.1 hypothetical protein -
M2890_RS26645 (M2890_26645) 92108..92566 - 459 WP_014386535.1 hypothetical protein -
M2890_RS26650 (M2890_26650) 93219..93674 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
M2890_RS26655 (M2890_26655) 93746..94111 + 366 WP_001294656.1 mercuric ion transporter MerT -
M2890_RS26660 (M2890_26660) 94127..94402 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
M2890_RS26665 (M2890_26665) 94430..94855 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..222331 222331


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T254386 WP_014386536.1 NZ_CP102884:c90229-89747 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT254386 WP_004902250.1 NZ_CP102884:c90498-90220 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References