Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5242437..5243062 Replicon chromosome
Accession NZ_CP102883
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag M2890_RS25775 Protein ID WP_004187928.1
Coordinates 5242437..5242820 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag M2890_RS25780 Protein ID WP_004150355.1
Coordinates 5242820..5243062 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS25760 (5239803) 5239803..5240705 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
M2890_RS25765 (5240702) 5240702..5241337 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
M2890_RS25770 (5241334) 5241334..5242263 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
M2890_RS25775 (5242437) 5242437..5242820 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
M2890_RS25780 (5242820) 5242820..5243062 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
M2890_RS25785 (5243256) 5243256..5244173 + 918 WP_032437488.1 alpha/beta hydrolase -
M2890_RS25790 (5244187) 5244187..5245128 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
M2890_RS25795 (5245173) 5245173..5245610 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
M2890_RS25800 (5245607) 5245607..5246467 - 861 WP_004146232.1 virulence factor BrkB family protein -
M2890_RS25805 (5246461) 5246461..5247060 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T254383 WP_004187928.1 NZ_CP102883:c5242820-5242437 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT254383 WP_004150355.1 NZ_CP102883:c5243062-5242820 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References