Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4920023..4921704 Replicon chromosome
Accession NZ_CP102883
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag M2890_RS24290 Protein ID WP_002885155.1
Coordinates 4920023..4920940 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag M2890_RS24295 Protein ID WP_004192584.1
Coordinates 4920946..4921704 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS24270 (4915329) 4915329..4916849 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M2890_RS24275 (4916846) 4916846..4917844 + 999 WP_002885172.1 ribose ABC transporter permease -
M2890_RS24280 (4917875) 4917875..4918816 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M2890_RS24285 (4918891) 4918891..4919898 + 1008 WP_004177805.1 carbohydrate kinase family protein -
M2890_RS24290 (4920023) 4920023..4920940 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M2890_RS24295 (4920946) 4920946..4921704 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M2890_RS24300 (4921790) 4921790..4922518 - 729 WP_002885152.1 response regulator transcription factor -
M2890_RS24305 (4922791) 4922791..4924938 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M2890_RS24310 (4925168) 4925168..4925854 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T254382 WP_002885155.1 NZ_CP102883:c4920940-4920023 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT254382 WP_004192584.1 NZ_CP102883:c4921704-4920946 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References