Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4751768..4752284 Replicon chromosome
Accession NZ_CP102883
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag M2890_RS23445 Protein ID WP_004192395.1
Coordinates 4751768..4752052 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag M2890_RS23450 Protein ID WP_004192397.1
Coordinates 4752042..4752284 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS23420 (4747185) 4747185..4747448 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
M2890_RS23425 (4747578) 4747578..4747751 + 174 WP_002886906.1 hypothetical protein -
M2890_RS23430 (4747754) 4747754..4748497 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M2890_RS23435 (4748854) 4748854..4750992 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M2890_RS23440 (4751300) 4751300..4751764 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M2890_RS23445 (4751768) 4751768..4752052 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2890_RS23450 (4752042) 4752042..4752284 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M2890_RS23455 (4752362) 4752362..4754272 - 1911 WP_004152270.1 PRD domain-containing protein -
M2890_RS23460 (4754295) 4754295..4755449 - 1155 WP_004178372.1 lactonase family protein -
M2890_RS23465 (4755516) 4755516..4756256 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T254381 WP_004192395.1 NZ_CP102883:c4752052-4751768 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT254381 WP_004192397.1 NZ_CP102883:c4752284-4752042 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References