Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4627050..4627860 Replicon chromosome
Accession NZ_CP102883
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name KacT Uniprot ID A0A483G813
Locus tag M2890_RS22855 Protein ID WP_023279404.1
Coordinates 4627050..4627583 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag M2890_RS22860 Protein ID WP_002887278.1
Coordinates 4627594..4627860 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS22850 (4625881) 4625881..4627002 + 1122 WP_002887282.1 cupin domain-containing protein -
M2890_RS22855 (4627050) 4627050..4627583 - 534 WP_023279404.1 type II toxin-antitoxin system toxin KacT Toxin
M2890_RS22860 (4627594) 4627594..4627860 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
M2890_RS22865 (4627963) 4627963..4629396 - 1434 WP_258323903.1 Cu(+)/Ag(+) sensor histidine kinase -
M2890_RS22870 (4629386) 4629386..4630069 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
M2890_RS22875 (4630241) 4630241..4631626 + 1386 WP_004192218.1 efflux transporter outer membrane subunit -
M2890_RS22880 (4631644) 4631644..4631988 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19809.71 Da        Isoelectric Point: 6.2369

>T254379 WP_023279404.1 NZ_CP102883:c4627583-4627050 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDKNSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT254379 WP_002887278.1 NZ_CP102883:c4627860-4627594 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483G813

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References