Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2640986..2642574 Replicon chromosome
Accession NZ_CP102883
Organism Klebsiella pneumoniae strain KH2

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag M2890_RS13105 Protein ID WP_004190166.1
Coordinates 2640986..2642308 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M2890_RS13110 Protein ID WP_002904790.1
Coordinates 2642308..2642574 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2890_RS13090 (2636042) 2636042..2638543 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
M2890_RS13095 (2638531) 2638531..2639535 + 1005 WP_004190163.1 fimbrial protein -
M2890_RS13100 (2639677) 2639677..2640969 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
M2890_RS13105 (2640986) 2640986..2642308 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
M2890_RS13110 (2642308) 2642308..2642574 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M2890_RS13115 (2642839) 2642839..2643165 - 327 WP_004143476.1 hydroxyisourate hydrolase -
M2890_RS13120 (2643162) 2643162..2643662 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M2890_RS13125 (2643640) 2643640..2645019 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
M2890_RS13130 (2645365) 2645365..2646519 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M2890_RS13135 (2646500) 2646500..2647423 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T254377 WP_004190166.1 NZ_CP102883:c2642308-2640986 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254377 WP_002904790.1 NZ_CP102883:c2642574-2642308 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References