254366

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 148459..148981 Replicon plasmid pKH1-1
Accession NZ_CP102878
Organism Klebsiella pneumoniae strain KH1

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag NWT87_RS26950 Protein ID WP_004181778.1
Coordinates 148697..148981 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag NWT87_RS26945 Protein ID WP_004181777.1
Coordinates 148459..148707 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT87_RS26925 (NWT87_26925) 143668..144489 - 822 WP_004181772.1 hypothetical protein -
NWT87_RS26930 (NWT87_26930) 144551..144904 - 354 WP_004181774.1 hypothetical protein -
NWT87_RS26935 (NWT87_26935) 145049..146035 - 987 WP_025368599.1 hypothetical protein -
NWT87_RS26940 (NWT87_26940) 146369..148168 - 1800 WP_004181776.1 ATP-dependent helicase -
NWT87_RS26945 (NWT87_26945) 148459..148707 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWT87_RS26950 (NWT87_26950) 148697..148981 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT87_RS26955 (NWT87_26955) 148998..149099 - 102 Protein_163 IS200/IS605 family transposase -
NWT87_RS26960 (NWT87_26960) 149135..150361 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
NWT87_RS26965 (NWT87_26965) 150632..150856 - 225 Protein_165 transposase -
NWT87_RS26970 (NWT87_26970) 150935..151363 - 429 WP_077257669.1 IS200/IS605 family transposase -
NWT87_RS26975 (NWT87_26975) 151399..152586 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
NWT87_RS26980 (NWT87_26980) 152631..153002 - 372 WP_040209644.1 hypothetical protein -
NWT87_RS26985 (NWT87_26985) 152999..153343 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..222330 222330


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T254366 WP_004181778.1 NZ_CP102878:148697-148981 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT254366 WP_004181777.1 NZ_CP102878:148459-148707 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References