254364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 46446..46972 Replicon plasmid pKH1-1
Accession NZ_CP102878
Organism Klebsiella pneumoniae strain KH1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NWT87_RS26400 Protein ID WP_000323025.1
Coordinates 46685..46972 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NWT87_RS26395 Protein ID WP_000534858.1
Coordinates 46446..46685 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT87_RS26375 (NWT87_26375) 42774..44012 + 1239 WP_003030308.1 IS110 family transposase -
NWT87_RS26380 (NWT87_26380) 44488..45060 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
NWT87_RS26385 (NWT87_26385) 45260..46183 + 924 WP_020277922.1 cation diffusion facilitator family transporter -
NWT87_RS26390 (NWT87_26390) 46317..46421 - 105 Protein_50 hypothetical protein -
NWT87_RS26395 (NWT87_26395) 46446..46685 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NWT87_RS26400 (NWT87_26400) 46685..46972 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NWT87_RS26405 (NWT87_26405) 47044..47202 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
NWT87_RS26410 (NWT87_26410) 47805..48056 + 252 WP_258323940.1 hypothetical protein -
NWT87_RS26415 (NWT87_26415) 48093..48797 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
NWT87_RS26420 (NWT87_26420) 48846..48971 - 126 Protein_56 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..222330 222330


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T254364 WP_000323025.1 NZ_CP102878:46685-46972 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT254364 WP_000534858.1 NZ_CP102878:46446-46685 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References