Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 46446..46972 Replicon plasmid pKH1-1
Accession NZ_CP102878
Organism Klebsiella pneumoniae strain KH1

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NWT87_RS26400 Protein ID WP_000323025.1
Coordinates 46685..46972 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NWT87_RS26395 Protein ID WP_000534858.1
Coordinates 46446..46685 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT87_RS26375 (NWT87_26375) 42774..44012 + 1239 WP_003030308.1 IS110 family transposase -
NWT87_RS26380 (NWT87_26380) 44488..45060 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
NWT87_RS26385 (NWT87_26385) 45260..46183 + 924 WP_020277922.1 cation diffusion facilitator family transporter -
NWT87_RS26390 (NWT87_26390) 46317..46421 - 105 Protein_50 hypothetical protein -
NWT87_RS26395 (NWT87_26395) 46446..46685 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NWT87_RS26400 (NWT87_26400) 46685..46972 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NWT87_RS26405 (NWT87_26405) 47044..47202 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
NWT87_RS26410 (NWT87_26410) 47805..48056 + 252 WP_258323940.1 hypothetical protein -
NWT87_RS26415 (NWT87_26415) 48093..48797 + 705 WP_001067858.1 IS6-like element IS26 family transposase -
NWT87_RS26420 (NWT87_26420) 48846..48971 - 126 Protein_56 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 1..222330 222330


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T254364 WP_000323025.1 NZ_CP102878:46685-46972 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT254364 WP_000534858.1 NZ_CP102878:46446-46685 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References