Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 36231..37141 | Replicon | plasmid pKH1-1 |
| Accession | NZ_CP102878 | ||
| Organism | Klebsiella pneumoniae strain KH1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A5Q9LR54 |
| Locus tag | NWT87_RS26350 | Protein ID | WP_004181896.1 |
| Coordinates | 36671..37141 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A2J4RLY9 |
| Locus tag | NWT87_RS26345 | Protein ID | WP_004181895.1 |
| Coordinates | 36231..36674 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWT87_RS26325 (NWT87_26325) | 31239..32459 | + | 1221 | WP_000343760.1 | ISL3-like element ISKox3 family transposase | - |
| NWT87_RS26330 (NWT87_26330) | 32864..34351 | + | 1488 | WP_023332914.1 | group II intron reverse transcriptase/maturase | - |
| NWT87_RS26335 (NWT87_26335) | 34437..34859 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| NWT87_RS26340 (NWT87_26340) | 34859..36130 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NWT87_RS26345 (NWT87_26345) | 36231..36674 | + | 444 | WP_004181895.1 | DUF2384 domain-containing protein | Antitoxin |
| NWT87_RS26350 (NWT87_26350) | 36671..37141 | + | 471 | WP_004181896.1 | RES family NAD+ phosphorylase | Toxin |
| NWT87_RS26355 (NWT87_26355) | 37251..37511 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| NWT87_RS26360 (NWT87_26360) | 38082..39263 | - | 1182 | WP_078207741.1 | IS481 family transposase | - |
| NWT87_RS26365 (NWT87_26365) | 39392..40924 | - | 1533 | WP_015065592.1 | IS3-like element ISKpn38 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | mph(A) / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 | - | 1..222330 | 222330 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17549.81 Da Isoelectric Point: 4.6155
>T254363 WP_004181896.1 NZ_CP102878:36671-37141 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16536.87 Da Isoelectric Point: 10.3013
>AT254363 WP_004181895.1 NZ_CP102878:36231-36674 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q9LR54 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J4RLY9 |