Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5242527..5243152 Replicon chromosome
Accession NZ_CP102877
Organism Klebsiella pneumoniae strain KH1

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag NWT87_RS25775 Protein ID WP_004187928.1
Coordinates 5242527..5242910 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NWT87_RS25780 Protein ID WP_004150355.1
Coordinates 5242910..5243152 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT87_RS25760 (5239893) 5239893..5240795 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NWT87_RS25765 (5240792) 5240792..5241427 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NWT87_RS25770 (5241424) 5241424..5242353 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NWT87_RS25775 (5242527) 5242527..5242910 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
NWT87_RS25780 (5242910) 5242910..5243152 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NWT87_RS25785 (5243346) 5243346..5244263 + 918 WP_032437488.1 alpha/beta hydrolase -
NWT87_RS25790 (5244277) 5244277..5245218 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NWT87_RS25795 (5245263) 5245263..5245700 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NWT87_RS25800 (5245697) 5245697..5246557 - 861 WP_004146232.1 virulence factor BrkB family protein -
NWT87_RS25805 (5246551) 5246551..5247150 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T254362 WP_004187928.1 NZ_CP102877:c5242910-5242527 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT254362 WP_004150355.1 NZ_CP102877:c5243152-5242910 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References