Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4751858..4752374 Replicon chromosome
Accession NZ_CP102877
Organism Klebsiella pneumoniae strain KH1

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag NWT87_RS23445 Protein ID WP_004192395.1
Coordinates 4751858..4752142 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag NWT87_RS23450 Protein ID WP_004192397.1
Coordinates 4752132..4752374 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT87_RS23420 (4747275) 4747275..4747538 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NWT87_RS23425 (4747668) 4747668..4747841 + 174 WP_002886906.1 hypothetical protein -
NWT87_RS23430 (4747844) 4747844..4748587 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NWT87_RS23435 (4748944) 4748944..4751082 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NWT87_RS23440 (4751390) 4751390..4751854 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NWT87_RS23445 (4751858) 4751858..4752142 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT87_RS23450 (4752132) 4752132..4752374 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NWT87_RS23455 (4752452) 4752452..4754362 - 1911 WP_004152270.1 PRD domain-containing protein -
NWT87_RS23460 (4754385) 4754385..4755539 - 1155 WP_004178372.1 lactonase family protein -
NWT87_RS23465 (4755606) 4755606..4756346 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T254360 WP_004192395.1 NZ_CP102877:c4752142-4751858 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT254360 WP_004192397.1 NZ_CP102877:c4752374-4752132 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References