Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 866423..867080 Replicon chromosome
Accession NZ_CP102877
Organism Klebsiella pneumoniae strain KH1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NWT87_RS04345 Protein ID WP_002916310.1
Coordinates 866670..867080 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NWT87_RS04340 Protein ID WP_002916312.1
Coordinates 866423..866689 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT87_RS04315 (861579) 861579..863012 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NWT87_RS04320 (863131) 863131..863859 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NWT87_RS04325 (863909) 863909..864220 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NWT87_RS04330 (864384) 864384..865043 + 660 WP_002916317.1 hemolysin III family protein -
NWT87_RS04335 (865194) 865194..866177 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NWT87_RS04340 (866423) 866423..866689 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NWT87_RS04345 (866670) 866670..867080 + 411 WP_002916310.1 protein YgfX Toxin
NWT87_RS04350 (867087) 867087..867608 - 522 WP_002916308.1 flavodoxin FldB -
NWT87_RS04355 (867709) 867709..868605 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NWT87_RS04360 (868628) 868628..869341 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWT87_RS04365 (869347) 869347..871080 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254351 WP_002916310.1 NZ_CP102877:866670-867080 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254351 WP_002916312.1 NZ_CP102877:866423-866689 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References