Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 5880..6405 | Replicon | plasmid pKA2-5 |
Accession | NZ_CP102874 | ||
Organism | Klebsiella pneumoniae strain KA2 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D4HQE7 |
Locus tag | NWT85_RS29140 | Protein ID | WP_013023785.1 |
Coordinates | 5880..6185 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | W8V2V6 |
Locus tag | NWT85_RS29145 | Protein ID | WP_001568025.1 |
Coordinates | 6187..6405 (-) | Length | 73 a.a. |
Genomic Context
Location: 1551..2177 (627 bp)
Type: Others
Protein ID: WP_004197649.1
Type: Others
Protein ID: WP_004197649.1
Location: 2174..2476 (303 bp)
Type: Others
Protein ID: WP_071571079.1
Type: Others
Protein ID: WP_071571079.1
Location: 6992..7222 (231 bp)
Type: Others
Protein ID: WP_001261282.1
Type: Others
Protein ID: WP_001261282.1
Location: 7219..7635 (417 bp)
Type: Others
Protein ID: WP_001044770.1
Type: Others
Protein ID: WP_001044770.1
Location: 7709..8605 (897 bp)
Type: Others
Protein ID: Protein_12
Type: Others
Protein ID: Protein_12
Location: 10418..10492 (75 bp)
Type: Others
Protein ID: Protein_15
Type: Others
Protein ID: Protein_15
Location: 2972..3766 (795 bp)
Type: Others
Protein ID: WP_004197635.1
Type: Others
Protein ID: WP_004197635.1
Location: 3964..4680 (717 bp)
Type: Others
Protein ID: Protein_4
Type: Others
Protein ID: Protein_4
Location: 4975..5289 (315 bp)
Type: Others
Protein ID: WP_053389906.1
Type: Others
Protein ID: WP_053389906.1
Location: 5316..5711 (396 bp)
Type: Others
Protein ID: WP_017899885.1
Type: Others
Protein ID: WP_017899885.1
Location: 5880..6185 (306 bp)
Type: Toxin
Protein ID: WP_013023785.1
Type: Toxin
Protein ID: WP_013023785.1
Location: 6187..6405 (219 bp)
Type: Antitoxin
Protein ID: WP_001568025.1
Type: Antitoxin
Protein ID: WP_001568025.1
Location: 6575..7035 (461 bp)
Type: Others
Protein ID: Protein_9
Type: Others
Protein ID: Protein_9
Location: 8656..9360 (705 bp)
Type: Others
Protein ID: WP_001067858.1
Type: Others
Protein ID: WP_001067858.1
Location: 9473..10288 (816 bp)
Type: Others
Protein ID: WP_000018326.1
Type: Others
Protein ID: WP_000018326.1
Location: 10542..11246 (705 bp)
Type: Others
Protein ID: WP_001067858.1
Type: Others
Protein ID: WP_001067858.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NWT85_RS29110 (NWT85_29110) | 1551..2177 | + | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
NWT85_RS29115 (NWT85_29115) | 2174..2476 | + | 303 | WP_071571079.1 | hypothetical protein | - |
NWT85_RS29120 (NWT85_29120) | 2972..3766 | - | 795 | WP_004197635.1 | site-specific integrase | - |
NWT85_RS29125 (NWT85_29125) | 3964..4680 | - | 717 | Protein_4 | hypothetical protein | - |
NWT85_RS29130 (NWT85_29130) | 4975..5289 | - | 315 | WP_053389906.1 | hypothetical protein | - |
NWT85_RS29135 (NWT85_29135) | 5316..5711 | - | 396 | WP_017899885.1 | hypothetical protein | - |
NWT85_RS29140 (NWT85_29140) | 5880..6185 | - | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
NWT85_RS29145 (NWT85_29145) | 6187..6405 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
NWT85_RS29150 (NWT85_29150) | 6575..7035 | - | 461 | Protein_9 | hypothetical protein | - |
NWT85_RS29155 (NWT85_29155) | 6992..7222 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | - |
NWT85_RS29160 (NWT85_29160) | 7219..7635 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | - |
NWT85_RS29165 (NWT85_29165) | 7709..8605 | + | 897 | Protein_12 | ATP-binding protein | - |
NWT85_RS29170 (NWT85_29170) | 8656..9360 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
NWT85_RS29175 (NWT85_29175) | 9473..10288 | - | 816 | WP_000018326.1 | aminoglycoside O-phosphotransferase APH(3')-Ia | - |
NWT85_RS29180 (NWT85_29180) | 10418..10492 | + | 75 | Protein_15 | IS6 family transposase | - |
NWT85_RS29185 (NWT85_29185) | 10542..11246 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | aph(3')-Ia / mph(E) / msr(E) / armA | - | 1..65073 | 65073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T254346 WP_013023785.1 NZ_CP102874:c6185-5880 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
Antitoxin
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZP8 |