Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5880..6405 Replicon plasmid pKA2-5
Accession NZ_CP102874
Organism Klebsiella pneumoniae strain KA2

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag NWT85_RS29140 Protein ID WP_013023785.1
Coordinates 5880..6185 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag NWT85_RS29145 Protein ID WP_001568025.1
Coordinates 6187..6405 (-) Length 73 a.a.

Genomic Context


NWT85_RS29110NWT85_RS29115NWT85_RS29155NWT85_RS29160NWT85_RS29165NWT85_RS29180NWT85_RS29120NWT85_RS29125NWT85_RS29130NWT85_RS29135NWT85_RS29140NWT85_RS29145NWT85_RS29150NWT85_RS29170NWT85_RS29175NWT85_RS29185
Location: 1551..2177 (627 bp)
Type: Others
Protein ID: WP_004197649.1
Location: 2174..2476 (303 bp)
Type: Others
Protein ID: WP_071571079.1
Location: 6992..7222 (231 bp)
Type: Others
Protein ID: WP_001261282.1
Location: 7219..7635 (417 bp)
Type: Others
Protein ID: WP_001044770.1
Location: 7709..8605 (897 bp)
Type: Others
Protein ID: Protein_12
Location: 10418..10492 (75 bp)
Type: Others
Protein ID: Protein_15
Location: 2972..3766 (795 bp)
Type: Others
Protein ID: WP_004197635.1
Location: 3964..4680 (717 bp)
Type: Others
Protein ID: Protein_4
Location: 4975..5289 (315 bp)
Type: Others
Protein ID: WP_053389906.1
Location: 5316..5711 (396 bp)
Type: Others
Protein ID: WP_017899885.1
Location: 5880..6185 (306 bp)
Type: Toxin
Protein ID: WP_013023785.1
Location: 6187..6405 (219 bp)
Type: Antitoxin
Protein ID: WP_001568025.1
Location: 6575..7035 (461 bp)
Type: Others
Protein ID: Protein_9
Location: 8656..9360 (705 bp)
Type: Others
Protein ID: WP_001067858.1
Location: 9473..10288 (816 bp)
Type: Others
Protein ID: WP_000018326.1
Location: 10542..11246 (705 bp)
Type: Others
Protein ID: WP_001067858.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NWT85_RS29110 (NWT85_29110)1551..2177+627WP_004197649.1ParA family plasmid-partitioning AAA ATPase-
NWT85_RS29115 (NWT85_29115)2174..2476+303WP_071571079.1hypothetical protein-
NWT85_RS29120 (NWT85_29120)2972..3766-795WP_004197635.1site-specific integrase-
NWT85_RS29125 (NWT85_29125)3964..4680-717Protein_4hypothetical protein-
NWT85_RS29130 (NWT85_29130)4975..5289-315WP_053389906.1hypothetical protein-
NWT85_RS29135 (NWT85_29135)5316..5711-396WP_017899885.1hypothetical protein-
NWT85_RS29140 (NWT85_29140)5880..6185-306WP_013023785.1type II toxin-antitoxin system toxin CcdBToxin
NWT85_RS29145 (NWT85_29145)6187..6405-219WP_001568025.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
NWT85_RS29150 (NWT85_29150)6575..7035-461Protein_9hypothetical protein-
NWT85_RS29155 (NWT85_29155)6992..7222+231WP_001261282.1type II toxin-antitoxin system VapB family antitoxin-
NWT85_RS29160 (NWT85_29160)7219..7635+417WP_001044770.1type II toxin-antitoxin system VapC family toxin-
NWT85_RS29165 (NWT85_29165)7709..8605+897Protein_12ATP-binding protein-
NWT85_RS29170 (NWT85_29170)8656..9360-705WP_001067858.1IS6-like element IS26 family transposase-
NWT85_RS29175 (NWT85_29175)9473..10288-816WP_000018326.1aminoglycoside O-phosphotransferase APH(3')-Ia-
NWT85_RS29180 (NWT85_29180)10418..10492+75Protein_15IS6 family transposase-
NWT85_RS29185 (NWT85_29185)10542..11246-705WP_001067858.1IS6-like element IS26 family transposase-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidaph(3')-Ia / mph(E) / msr(E) / armA-1..6507365073


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-100)

Antitoxin

(2-72)


Sequences


Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T254346 WP_013023785.1 NZ_CP102874:c6185-5880 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp


Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT254346 WP_001568025.1 NZ_CP102874:c6405-6187 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2J4ZZW6


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A2J4ZZP8

References