Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 138709..139361 Replicon plasmid pKA2-1
Accession NZ_CP102870
Organism Klebsiella pneumoniae strain KA2

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag NWT85_RS26545 Protein ID WP_017901321.1
Coordinates 138709..139134 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag NWT85_RS26550 Protein ID WP_001261275.1
Coordinates 139131..139361 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT85_RS26520 (NWT85_26520) 134840..135067 + 228 Protein_152 IS3 family transposase -
NWT85_RS26525 (NWT85_26525) 135159..136715 - 1557 WP_025999314.1 sensor domain-containing diguanylate cyclase -
NWT85_RS26530 (NWT85_26530) 136902..137075 - 174 Protein_154 nuclease -
NWT85_RS26535 (NWT85_26535) 137128..137664 - 537 Protein_155 integrase core domain-containing protein -
NWT85_RS26540 (NWT85_26540) 137723..138691 - 969 WP_258335048.1 IS5 family transposase -
NWT85_RS26545 (NWT85_26545) 138709..139134 - 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
NWT85_RS26550 (NWT85_26550) 139131..139361 - 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NWT85_RS26555 (NWT85_26555) 139614..142190 - 2577 WP_017901322.1 nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA12 / aadA2 / qacE / sul1 / mph(A) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / tet(A) / mph(E) / msr(E) / armA / blaDHA-1 / qnrB4 / blaTEM-1B / aac(3)-IId - 1..257713 257713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T254343 WP_017901321.1 NZ_CP102870:c139134-138709 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT254343 WP_001261275.1 NZ_CP102870:c139361-139131 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References