Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 52314..53224 | Replicon | plasmid pKA2-1 |
| Accession | NZ_CP102870 | ||
| Organism | Klebsiella pneumoniae strain KA2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | NWT85_RS26045 | Protein ID | WP_004144067.1 |
| Coordinates | 52754..53224 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6A8PHD0 |
| Locus tag | NWT85_RS26040 | Protein ID | WP_023287184.1 |
| Coordinates | 52314..52757 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NWT85_RS26020 (NWT85_26020) | 47730..48479 | + | 750 | Protein_52 | IS5 family transposase | - |
| NWT85_RS26025 (NWT85_26025) | 48508..49476 | + | 969 | WP_074424072.1 | IS5 family transposase | - |
| NWT85_RS26030 (NWT85_26030) | 49672..51018 | + | 1347 | WP_225517490.1 | ThiF family adenylyltransferase | - |
| NWT85_RS26035 (NWT85_26035) | 51071..52213 | + | 1143 | Protein_55 | translesion error-prone DNA polymerase V subunit UmuC | - |
| NWT85_RS26040 (NWT85_26040) | 52314..52757 | + | 444 | WP_023287184.1 | DUF2384 domain-containing protein | Antitoxin |
| NWT85_RS26045 (NWT85_26045) | 52754..53224 | + | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| NWT85_RS26050 (NWT85_26050) | 53311..54306 | + | 996 | WP_210408685.1 | IS5 family transposase | - |
| NWT85_RS26055 (NWT85_26055) | 54308..55276 | + | 969 | WP_072096747.1 | IS5 family transposase | - |
| NWT85_RS26060 (NWT85_26060) | 55465..55725 | - | 261 | WP_017901409.1 | hypothetical protein | - |
| NWT85_RS26065 (NWT85_26065) | 56030..56998 | + | 969 | WP_074423483.1 | IS5 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | dfrA12 / aadA2 / qacE / sul1 / mph(A) / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / tet(A) / mph(E) / msr(E) / armA / blaDHA-1 / qnrB4 / blaTEM-1B / aac(3)-IId | - | 1..257713 | 257713 | |
| - | inside | IScluster/Tn | - | - | 45586..56998 | 11412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T254341 WP_004144067.1 NZ_CP102870:52754-53224 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16522.84 Da Isoelectric Point: 10.3013
>AT254341 WP_023287184.1 NZ_CP102870:52314-52757 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A8PHD0 |