Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4730431..4730947 Replicon chromosome
Accession NZ_CP102869
Organism Klebsiella pneumoniae strain KA2

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NWT85_RS23125 Protein ID WP_004178374.1
Coordinates 4730431..4730715 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NWT85_RS23130 Protein ID WP_002886901.1
Coordinates 4730705..4730947 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT85_RS23100 (NWT85_23100) 4725827..4726090 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NWT85_RS23105 (NWT85_23105) 4726220..4726393 + 174 WP_032103426.1 hypothetical protein -
NWT85_RS23110 (NWT85_23110) 4726396..4727139 + 744 WP_258334896.1 MurR/RpiR family transcriptional regulator -
NWT85_RS23115 (NWT85_23115) 4727496..4729634 + 2139 WP_255081622.1 anaerobic ribonucleoside-triphosphate reductase -
NWT85_RS23120 (NWT85_23120) 4729963..4730427 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NWT85_RS23125 (NWT85_23125) 4730431..4730715 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWT85_RS23130 (NWT85_23130) 4730705..4730947 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NWT85_RS23135 (NWT85_23135) 4731025..4732935 - 1911 WP_015959311.1 PRD domain-containing protein -
NWT85_RS23140 (NWT85_23140) 4732958..4734112 - 1155 WP_004178372.1 lactonase family protein -
NWT85_RS23145 (NWT85_23145) 4734179..4734919 - 741 WP_015959310.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T254339 WP_004178374.1 NZ_CP102869:c4730715-4730431 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254339 WP_002886901.1 NZ_CP102869:c4730947-4730705 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References