Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2644432..2646020 Replicon chromosome
Accession NZ_CP102869
Organism Klebsiella pneumoniae strain KA2

Toxin (Protein)


Gene name hipA Uniprot ID A6T928
Locus tag NWT85_RS13080 Protein ID WP_004176197.1
Coordinates 2644432..2645754 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NWT85_RS13085 Protein ID WP_002904790.1
Coordinates 2645754..2646020 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT85_RS13065 (NWT85_13065) 2639488..2641989 + 2502 WP_258335027.1 fimbria/pilus outer membrane usher protein -
NWT85_RS13070 (NWT85_13070) 2641977..2642981 + 1005 WP_032434525.1 fimbrial protein -
NWT85_RS13075 (NWT85_13075) 2643123..2644415 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NWT85_RS13080 (NWT85_13080) 2644432..2645754 - 1323 WP_004176197.1 type II toxin-antitoxin system HipA family toxin Toxin
NWT85_RS13085 (NWT85_13085) 2645754..2646020 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NWT85_RS13090 (NWT85_13090) 2646286..2646612 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NWT85_RS13095 (NWT85_13095) 2646609..2647109 - 501 WP_032434523.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NWT85_RS13100 (NWT85_13100) 2647087..2648466 - 1380 WP_258334794.1 nucleobase:cation symporter-2 family protein -
NWT85_RS13105 (NWT85_13105) 2648812..2649966 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NWT85_RS13110 (NWT85_13110) 2649947..2650870 - 924 WP_258334795.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49111.41 Da        Isoelectric Point: 7.5357

>T254336 WP_004176197.1 NZ_CP102869:c2645754-2644432 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254336 WP_002904790.1 NZ_CP102869:c2646020-2645754 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6T928

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References