Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 857802..858459 Replicon chromosome
Accession NZ_CP102869
Organism Klebsiella pneumoniae strain KA2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NWT85_RS04305 Protein ID WP_002916310.1
Coordinates 858049..858459 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NWT85_RS04300 Protein ID WP_002916312.1
Coordinates 857802..858068 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWT85_RS04275 (NWT85_04275) 852958..854391 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NWT85_RS04280 (NWT85_04280) 854510..855238 - 729 WP_258335030.1 MurR/RpiR family transcriptional regulator -
NWT85_RS04285 (NWT85_04285) 855288..855599 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NWT85_RS04290 (NWT85_04290) 855763..856422 + 660 WP_002916317.1 hemolysin III family protein -
NWT85_RS04295 (NWT85_04295) 856573..857556 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NWT85_RS04300 (NWT85_04300) 857802..858068 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NWT85_RS04305 (NWT85_04305) 858049..858459 + 411 WP_002916310.1 protein YgfX Toxin
NWT85_RS04310 (NWT85_04310) 858466..858987 - 522 WP_002916308.1 flavodoxin FldB -
NWT85_RS04315 (NWT85_04315) 859088..859984 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NWT85_RS04320 (NWT85_04320) 860007..860720 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWT85_RS04325 (NWT85_04325) 860726..862459 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254331 WP_002916310.1 NZ_CP102869:858049-858459 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254331 WP_002916312.1 NZ_CP102869:857802-858068 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References