Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 77381..77916 Replicon plasmid p573-4
Accession NZ_CP102857
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name relE Uniprot ID A0A0K4CX11
Locus tag NWH85_RS25955 Protein ID WP_000222771.1
Coordinates 77381..77668 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T1PXV2
Locus tag NWH85_RS25960 Protein ID WP_001139206.1
Coordinates 77665..77916 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS25940 (NWH85_26015) 73006..76521 + 3516 WP_258334562.1 autotransporter outer membrane beta-barrel domain-containing protein -
NWH85_RS25945 (NWH85_26020) 76696..76901 - 206 Protein_71 hypothetical protein -
NWH85_RS25950 (NWH85_26025) 76900..77013 + 114 Protein_72 alkaline phosphatase -
NWH85_RS25955 (NWH85_26030) 77381..77668 - 288 WP_000222771.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWH85_RS25960 (NWH85_26035) 77665..77916 - 252 WP_001139206.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NWH85_RS25965 (NWH85_26040) 78529..80346 + 1818 Protein_75 helicase -
NWH85_RS25970 (NWH85_26045) 80380..80820 + 441 WP_180390251.1 peptide-binding protein -
NWH85_RS25975 (NWH85_26050) 80817..81065 + 249 WP_000747846.1 hypothetical protein -
NWH85_RS25980 (NWH85_26055) 81104..81825 - 722 Protein_78 helix-turn-helix domain-containing protein -
NWH85_RS25985 (NWH85_26060) 82185..82748 + 564 WP_225877543.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..89244 89244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11116.17 Da        Isoelectric Point: 10.5833

>T254322 WP_000222771.1 NZ_CP102857:c77668-77381 [Escherichia coli]
MTYTVKFRDDALKEWLRLDKTIQQQFAKKLKKCSENPHIASAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYHLASERMK

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9171.39 Da        Isoelectric Point: 4.0927

>AT254322 WP_001139206.1 NZ_CP102857:c77916-77665 [Escherichia coli]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K4CX11

Antitoxin

Source ID Structure
AlphaFold DB T1PXV2

References