Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4118688..4119283 Replicon chromosome
Accession NZ_CP102853
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NWH85_RS20070 Protein ID WP_000239579.1
Coordinates 4118688..4119038 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NWH85_RS20075 Protein ID WP_001223208.1
Coordinates 4119032..4119283 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS20050 (4113964) 4113964..4114986 - 1023 WP_001339490.1 ABC transporter permease -
NWH85_RS20055 (4115000) 4115000..4116502 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
NWH85_RS20060 (4116812) 4116812..4117768 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NWH85_RS20065 (4118078) 4118078..4118608 + 531 WP_000055072.1 inorganic diphosphatase -
NWH85_RS20070 (4118688) 4118688..4119038 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NWH85_RS20075 (4119032) 4119032..4119283 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NWH85_RS20080 (4119496) 4119496..4119837 - 342 WP_063100134.1 gamma-glutamylcyclotransferase -
NWH85_RS20085 (4119840) 4119840..4123619 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T254304 WP_000239579.1 NZ_CP102853:c4119038-4118688 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT254304 WP_001223208.1 NZ_CP102853:c4119283-4119032 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References