Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3446208..3446826 Replicon chromosome
Accession NZ_CP102853
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NWH85_RS16925 Protein ID WP_001291435.1
Coordinates 3446608..3446826 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NWH85_RS16920 Protein ID WP_000344800.1
Coordinates 3446208..3446582 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS16910 (3441297) 3441297..3442490 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NWH85_RS16915 (3442513) 3442513..3445662 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NWH85_RS16920 (3446208) 3446208..3446582 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NWH85_RS16925 (3446608) 3446608..3446826 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NWH85_RS16930 (3446998) 3446998..3447549 + 552 WP_000102568.1 maltose O-acetyltransferase -
NWH85_RS16935 (3447665) 3447665..3448135 + 471 WP_000136192.1 YlaC family protein -
NWH85_RS16940 (3448299) 3448299..3449849 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NWH85_RS16945 (3449891) 3449891..3450244 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NWH85_RS16955 (3450623) 3450623..3450934 + 312 WP_000409911.1 MGMT family protein -
NWH85_RS16960 (3450965) 3450965..3451537 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T254301 WP_001291435.1 NZ_CP102853:3446608-3446826 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT254301 WP_000344800.1 NZ_CP102853:3446208-3446582 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References