Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2448228..2448866 Replicon chromosome
Accession NZ_CP102853
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NWH85_RS11955 Protein ID WP_000813794.1
Coordinates 2448690..2448866 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NWH85_RS11950 Protein ID WP_001270286.1
Coordinates 2448228..2448644 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS11930 (2443380) 2443380..2444321 - 942 WP_001251319.1 ABC transporter permease -
NWH85_RS11935 (2444322) 2444322..2445335 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NWH85_RS11940 (2445353) 2445353..2446498 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NWH85_RS11945 (2446743) 2446743..2448149 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
NWH85_RS11950 (2448228) 2448228..2448644 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NWH85_RS11955 (2448690) 2448690..2448866 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NWH85_RS11960 (2449088) 2449088..2449318 + 231 WP_000494244.1 YncJ family protein -
NWH85_RS11965 (2449410) 2449410..2451371 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NWH85_RS11970 (2451444) 2451444..2451980 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
NWH85_RS11975 (2452072) 2452072..2453247 + 1176 WP_001236319.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2453287..2454552 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T254300 WP_000813794.1 NZ_CP102853:c2448866-2448690 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT254300 WP_001270286.1 NZ_CP102853:c2448644-2448228 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References