Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1333179..1333804 Replicon chromosome
Accession NZ_CP102853
Organism Escherichia coli strain 573

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NWH85_RS06535 Protein ID WP_000911330.1
Coordinates 1333406..1333804 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NWH85_RS06530 Protein ID WP_000450524.1
Coordinates 1333179..1333406 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWH85_RS06505 (1328982) 1328982..1329452 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NWH85_RS06510 (1329452) 1329452..1330024 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NWH85_RS06515 (1330170) 1330170..1331048 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NWH85_RS06520 (1331065) 1331065..1332099 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NWH85_RS06525 (1332312) 1332312..1333025 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NWH85_RS06530 (1333179) 1333179..1333406 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NWH85_RS06535 (1333406) 1333406..1333804 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NWH85_RS06540 (1333951) 1333951..1334814 + 864 WP_001267508.1 neutral zinc metallopeptidase -
NWH85_RS06545 (1334829) 1334829..1336844 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
NWH85_RS06550 (1336918) 1336918..1337616 + 699 WP_000679823.1 esterase -
NWH85_RS06555 (1337726) 1337726..1337926 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T254293 WP_000911330.1 NZ_CP102853:1333406-1333804 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT254293 WP_000450524.1 NZ_CP102853:1333179-1333406 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References