Detailed information of TA system TA025429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 2182812..2183319
• Replicon: chromosome
• Accession: NC_015738
• Organism: Eggerthella sp. YY7918

Toxin (Protein)

• Gene name: -
• Uniprot ID: F7UVA6
• Locus tag: EGYY_RS09205
• Protein ID: WP_013980373.1
• Coordinates: 2182812..2183078 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: EGYY_RS09210
• Protein ID: WP_198408577.1
• Coordinates: 2183122..2183319 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGYY_RS09170	2178682..2178993	-	312	WP_013980366.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
EGYY_RS09175	2179282..2179569	+	288	WP_013980367.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
EGYY_RS09180	2179557..2179916	+	360	WP_151197466.1	type II toxin-antitoxin system PemK/MazF family toxin	-
EGYY_RS09185	2180031..2180345	+	315	WP_013980369.1	PadR family transcriptional regulator	-
EGYY_RS13420	2180342..2181055	+	714	WP_013980370.1	DUF1700 domain-containing protein	-
EGYY_RS09195	2181039..2182226	+	1188	WP_013980371.1	DUF4097 family beta strand repeat protein	-
EGYY_RS09200	2182346..2182636	-	291	WP_013980372.1	hypothetical protein	-
EGYY_RS09205	2182812..2183078	+	267	WP_013980373.1	BrnT family toxin	Toxin
EGYY_RS09210	2183122..2183319	+	198	WP_198408577.1	CopG family transcriptional regulator	Antitoxin
EGYY_RS09215	2183339..2185363	-	2025	WP_013980375.1	ATP-dependent DNA helicase	-
EGYY_RS09220	2185447..2186730	+	1284	WP_013980376.1	serpin family protein	-
EGYY_RS09225	2186727..2188040	-	1314	WP_013980377.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10240.55 Da
• Isoelectric Point: 9.4003

>T25429 WP_013980373.1 NC_015738:2182812-2183078 [Eggerthella sp. YY7918]
MKFEYDPAKSAGNLIKHGIDFEKAQELWNSKTIELESKAYVSEHRTLVLGKIEGKHWTAIVTERGDATRIISVRRSRQKE
ARYYDETN

Nucleotide

• Length: 267 bp

>T25429 NC_015738:2182812-2183078 [Eggerthella sp. YY7918]
ATGAAGTTTGAATATGACCCAGCAAAAAGTGCAGGCAACCTTATCAAACACGGCATAGACTTCGAAAAAGCTCAAGAACT
TTGGAATAGTAAAACAATAGAACTAGAATCAAAAGCATATGTTAGCGAGCATCGTACCCTCGTTCTGGGAAAGATAGAGG
GAAAGCACTGGACAGCTATCGTTACCGAACGTGGTGACGCAACGCGAATCATCTCCGTCAGGCGCTCAAGACAGAAGGAG
GCGCGCTATTATGACGAAACAAATTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7793.91 Da
• Isoelectric Point: 6.7237

>AT25429 WP_198408577.1 NC_015738:2183122-2183319 [Eggerthella sp. YY7918]
MDHFDVRHPIIRNDGSVRRVSVDMPEWMIEQLDDEARHLAVPRQAIIKIWLSERLERQSQARQMS

Nucleotide

• Length: 198 bp

>AT25429 NC_015738:2183122-2183319 [Eggerthella sp. YY7918]
ATGGACCACTTTGACGTAAGGCACCCTATTATAAGAAACGACGGCAGTGTACGACGCGTAAGTGTCGACATGCCCGAATG
GATGATCGAGCAACTCGACGACGAGGCTCGACACTTAGCCGTCCCTCGTCAGGCAATTATTAAAATATGGCTTTCTGAGC
GACTTGAAAGACAGAGCCAAGCTCGACAAATGTCTTAG

Structures

Toxin

• AlphaFold DB: F7UVA6