Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 5073830..5074362 Replicon chromosome
Accession NZ_CP102850
Organism Gordonia mangrovi strain HNM0687

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NWF22_RS23005 Protein ID WP_160902223.1
Coordinates 5073830..5074162 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NWF22_RS23010 Protein ID WP_160902222.1
Coordinates 5074159..5074362 (-) Length 68 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWF22_RS22980 (NWF22_22980) 5069315..5069809 - 495 WP_258321254.1 hypothetical protein -
NWF22_RS22985 (NWF22_22985) 5070771..5071448 - 678 WP_160902227.1 hypothetical protein -
NWF22_RS22990 (NWF22_22990) 5071445..5072143 - 699 WP_160902226.1 hypothetical protein -
NWF22_RS22995 (NWF22_22995) 5072994..5073395 - 402 WP_160902225.1 type II toxin-antitoxin system VapC family toxin -
NWF22_RS23000 (NWF22_23000) 5073422..5073661 - 240 WP_160902224.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
NWF22_RS23005 (NWF22_23005) 5073830..5074162 - 333 WP_160902223.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NWF22_RS23010 (NWF22_23010) 5074159..5074362 - 204 WP_160902222.1 DUF3018 family protein Antitoxin
NWF22_RS23015 (NWF22_23015) 5074452..5074616 - 165 WP_258321255.1 antitoxin MazE family protein -
NWF22_RS23020 (NWF22_23020) 5074787..5075173 - 387 WP_160904327.1 type II toxin-antitoxin system VapC family toxin -
NWF22_RS23025 (NWF22_23025) 5075170..5075298 - 129 WP_258321256.1 hypothetical protein -
NWF22_RS23030 (NWF22_23030) 5075671..5076057 - 387 WP_160904326.1 hypothetical protein -
NWF22_RS23035 (NWF22_23035) 5076057..5076698 - 642 WP_160904325.1 nucleotidyltransferase domain-containing protein -
NWF22_RS23040 (NWF22_23040) 5077946..5078245 - 300 WP_258321257.1 type II toxin-antitoxin system PemK/MazF family toxin -
NWF22_RS23045 (NWF22_23045) 5078247..5078480 - 234 WP_160904323.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5070218..5078510 8292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-108)

Antitoxin

(4-65)


Sequences


Toxin        


Download         Length: 111 a.a.        Molecular weight: 12075.02 Da        Isoelectric Point: 6.3330

>T254287 WP_160902223.1 NZ_CP102850:c5074162-5073830 [Gordonia mangrovi]
VIRGEIWTVAGGVYASKPRPAVIVQDDLFDSTLSVVVAPMTSQLIEAPLLRIRIPGDRDTISGLDRDSDVMIDKLTAVRR
SNVLTRVGRLTSEQLVEVERSLMAFLGLAR

Download         Length: 333 bp


Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7591.49 Da        Isoelectric Point: 4.7361

>AT254287 WP_160902222.1 NZ_CP102850:c5074362-5074159 [Gordonia mangrovi]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTPEFAAQAHAQSVLVAQADEGEQGFVEAVAAPWDDEA

Download         Length: 204 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References