254279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 10732..11312 Replicon plasmid pKP4863-2
Accession NZ_CP102843
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag NV397_RS26635 Protein ID WP_001136729.1
Coordinates 10732..11046 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NV397_RS26640 Protein ID WP_000093040.1
Coordinates 11034..11312 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS26610 (NV397_26610) 6678..8639 + 1962 WP_065799589.1 TraM recognition domain-containing protein -
NV397_RS26615 (NV397_26615) 8639..9370 + 732 WP_032448355.1 MobC family replication-relaxation protein -
NV397_RS26620 (NV397_26620) 9377..9907 + 531 WP_065521056.1 hypothetical protein -
NV397_RS26625 (NV397_26625) 9935..10114 - 180 WP_065521055.1 Rop family plasmid primer RNA-binding protein -
NV397_RS26630 (NV397_26630) 10140..10568 - 429 WP_001140599.1 hypothetical protein -
NV397_RS26635 (NV397_26635) 10732..11046 - 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV397_RS26640 (NV397_26640) 11034..11312 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NV397_RS26645 (NV397_26645) 11633..11851 - 219 WP_002193751.1 TonB family protein -
NV397_RS26650 (NV397_26650) 11848..12219 - 372 WP_001237044.1 cell envelope integrity protein TolA -
NV397_RS26655 (NV397_26655) 12493..12738 - 246 WP_004146442.1 hypothetical protein -
NV397_RS26660 (NV397_26660) 13065..14750 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
NV397_RS26665 (NV397_26665) 14760..15017 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
NV397_RS26670 (NV397_26670) 15102..15251 + 150 WP_219386769.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..20110 20110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T254279 WP_001136729.1 NZ_CP102843:c11046-10732 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT254279 WP_000093040.1 NZ_CP102843:c11312-11034 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References