254278

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 677..1257 Replicon plasmid pKP4863-2
Accession NZ_CP102843
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag NV397_RS26570 Protein ID WP_001136729.1
Coordinates 677..991 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NV397_RS26575 Protein ID WP_000093040.1
Coordinates 979..1257 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS26565 (NV397_26565) 85..513 - 429 WP_001140599.1 hypothetical protein -
NV397_RS26570 (NV397_26570) 677..991 - 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV397_RS26575 (NV397_26575) 979..1257 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NV397_RS26580 (NV397_26580) 1578..1796 - 219 WP_002193751.1 TonB family protein -
NV397_RS26585 (NV397_26585) 1793..2164 - 372 WP_001237044.1 cell envelope integrity protein TolA -
NV397_RS26590 (NV397_26590) 2438..2683 - 246 WP_004146442.1 hypothetical protein -
NV397_RS26595 (NV397_26595) 3010..4695 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
NV397_RS26600 (NV397_26600) 4705..4962 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
NV397_RS26605 (NV397_26605) 5047..5196 + 150 WP_219386769.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..20110 20110


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T254278 WP_001136729.1 NZ_CP102843:c991-677 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT254278 WP_000093040.1 NZ_CP102843:c1257-979 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References