Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 51792..52435 Replicon plasmid pKP4863-1
Accession NZ_CP102842
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NV397_RS25805 Protein ID WP_094309080.1
Coordinates 51792..52208 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A6B7Q5S4
Locus tag NV397_RS25810 Protein ID WP_021312476.1
Coordinates 52205..52435 (-) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS25765 (NV397_25765) 47024..47854 + 831 WP_074425395.1 AraC family transcriptional regulator -
NV397_RS25770 (NV397_25770) 47985..48110 - 126 Protein_53 IS481 family transposase -
NV397_RS25775 (NV397_25775) 48101..48496 - 396 Protein_54 DNA-binding protein -
NV397_RS25780 (NV397_25780) 48527..49099 - 573 WP_094309628.1 hypothetical protein -
NV397_RS25785 (NV397_25785) 49104..49352 - 249 WP_065801593.1 hypothetical protein -
NV397_RS25790 (NV397_25790) 49631..50637 - 1007 Protein_57 IS110 family transposase -
NV397_RS25795 (NV397_25795) 51194..51448 - 255 WP_065801592.1 hypothetical protein -
NV397_RS25800 (NV397_25800) 51512..51757 - 246 WP_181936996.1 hypothetical protein -
NV397_RS25805 (NV397_25805) 51792..52208 - 417 WP_094309080.1 type II toxin-antitoxin system VapC family toxin Toxin
NV397_RS25810 (NV397_25810) 52205..52435 - 231 WP_021312476.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NV397_RS25815 (NV397_25815) 52807..53319 - 513 WP_065801590.1 hypothetical protein -
NV397_RS25820 (NV397_25820) 53624..54964 + 1341 WP_225579868.1 hypothetical protein -
NV397_RS25825 (NV397_25825) 55015..55437 - 423 WP_077269076.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul2 / dfrA12 / aadA2 / qacE cseA / iucA / iucB / iucC / iucD / iutA 1..186106 186106


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 14989.47 Da        Isoelectric Point: 9.2738

>T254277 WP_094309080.1 NZ_CP102842:c52208-51792 [Klebsiella pneumoniae]
VKKTFMLDTKICSFIMREQPAAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVDATTEIKVALRQAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLVLEDWVN

Download         Length: 417 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8723.76 Da        Isoelectric Point: 4.3410

>AT254277 WP_021312476.1 NZ_CP102842:c52435-52205 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDL

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A6B7Q5S4

References