Detailed information of TA system TA254274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4882239..4883920
• Replicon: chromosome
• Accession: NZ_CP102841
• Organism: Klebsiella pneumoniae strain KP4863

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: NV397_RS23635
• Protein ID: WP_015959269.1
• Coordinates: 4882239..4883114 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NV397_RS23640
• Protein ID: WP_004177809.1
• Coordinates: 4883162..4883920 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NV397_RS23615 (NV397_23615)	4877545..4879065	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
NV397_RS23620 (NV397_23620)	4879062..4880060	+	999	WP_002885172.1	ribose ABC transporter permease	-
NV397_RS23625 (NV397_23625)	4880091..4881032	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
NV397_RS23630 (NV397_23630)	4881107..4882114	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
NV397_RS23635 (NV397_23635)	4882239..4883114	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NV397_RS23640 (NV397_23640)	4883162..4883920	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NV397_RS23645 (NV397_23645)	4884006..4884734	-	729	WP_002885152.1	response regulator transcription factor	-
NV397_RS23650 (NV397_23650)	4885007..4887154	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NV397_RS23655 (NV397_23655)	4887384..4888070	+	687	WP_032413196.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T254274 WP_015959269.1 NZ_CP102841:c4883114-4882239 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT254274 WP_004177809.1 NZ_CP102841:c4883920-4883162 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05