Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4710600..4711116 Replicon chromosome
Accession NZ_CP102841
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag NV397_RS22780 Protein ID WP_004178374.1
Coordinates 4710600..4710884 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NV397_RS22785 Protein ID WP_002886901.1
Coordinates 4710874..4711116 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS22755 (NV397_22755) 4705996..4706259 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
NV397_RS22760 (NV397_22760) 4706389..4706562 + 174 WP_002886906.1 hypothetical protein -
NV397_RS22765 (NV397_22765) 4706565..4707308 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NV397_RS22770 (NV397_22770) 4707665..4709803 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NV397_RS22775 (NV397_22775) 4710132..4710596 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NV397_RS22780 (NV397_22780) 4710600..4710884 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV397_RS22785 (NV397_22785) 4710874..4711116 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NV397_RS22790 (NV397_22790) 4711193..4713103 - 1911 WP_048299762.1 PRD domain-containing protein -
NV397_RS22795 (NV397_22795) 4713126..4714280 - 1155 WP_002886900.1 lactonase family protein -
NV397_RS22800 (NV397_22800) 4714347..4715087 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T254273 WP_004178374.1 NZ_CP102841:c4710884-4710600 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254273 WP_002886901.1 NZ_CP102841:c4711116-4710874 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References