Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4605315..4606125 Replicon chromosome
Accession NZ_CP102841
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag NV397_RS22320 Protein ID WP_101968539.1
Coordinates 4605315..4605848 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NV397_RS22325 Protein ID WP_002887278.1
Coordinates 4605859..4606125 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS22315 (NV397_22315) 4604146..4605267 + 1122 WP_009309849.1 cupin domain-containing protein -
NV397_RS22320 (NV397_22320) 4605315..4605848 - 534 WP_101968539.1 type II toxin-antitoxin system toxin KacT Toxin
NV397_RS22325 (NV397_22325) 4605859..4606125 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NV397_RS22330 (NV397_22330) 4606228..4607661 - 1434 WP_065782632.1 Cu(+)/Ag(+) sensor histidine kinase -
NV397_RS22335 (NV397_22335) 4607651..4608334 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NV397_RS22340 (NV397_22340) 4608507..4609892 + 1386 WP_135702016.1 efflux transporter outer membrane subunit -
NV397_RS22345 (NV397_22345) 4609910..4610254 + 345 WP_032433444.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(89-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19826.69 Da        Isoelectric Point: 5.2614

>T254272 WP_101968539.1 NZ_CP102841:c4605848-4605315 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLLSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT254272 WP_002887278.1 NZ_CP102841:c4606125-4605859 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References