Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2653752..2655340 Replicon chromosome
Accession NZ_CP102841
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NV397_RS12875 Protein ID WP_258240633.1
Coordinates 2653752..2655074 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NV397_RS12880 Protein ID WP_004176198.1
Coordinates 2655074..2655340 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS12860 (NV397_12860) 2648808..2651309 + 2502 WP_021462557.1 fimbria/pilus outer membrane usher protein -
NV397_RS12865 (NV397_12865) 2651297..2652301 + 1005 WP_004190163.1 fimbrial protein -
NV397_RS12870 (NV397_12870) 2652443..2653735 + 1293 WP_163622032.1 glycoside hydrolase family 10 protein -
NV397_RS12875 (NV397_12875) 2653752..2655074 - 1323 WP_258240633.1 type II toxin-antitoxin system HipA family toxin Toxin
NV397_RS12880 (NV397_12880) 2655074..2655340 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NV397_RS12885 (NV397_12885) 2655605..2655931 - 327 WP_004215084.1 hydroxyisourate hydrolase -
NV397_RS12890 (NV397_12890) 2655928..2656428 - 501 WP_004215086.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NV397_RS12895 (NV397_12895) 2656406..2657785 - 1380 WP_163622035.1 nucleobase:cation symporter-2 family protein -
NV397_RS12900 (NV397_12900) 2658131..2659285 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NV397_RS12905 (NV397_12905) 2659266..2660189 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49145.43 Da        Isoelectric Point: 7.5357

>T254269 WP_258240633.1 NZ_CP102841:c2655074-2653752 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARALSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT254269 WP_004176198.1 NZ_CP102841:c2655340-2655074 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References