Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805499..806156 Replicon chromosome
Accession NZ_CP102841
Organism Klebsiella pneumoniae strain KP4863

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NV397_RS03985 Protein ID WP_002916310.1
Coordinates 805746..806156 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NV397_RS03980 Protein ID WP_002916312.1
Coordinates 805499..805765 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV397_RS03955 (NV397_03955) 800655..802088 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NV397_RS03960 (NV397_03960) 802207..802935 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NV397_RS03965 (NV397_03965) 802985..803296 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NV397_RS03970 (NV397_03970) 803460..804119 + 660 WP_002916317.1 hemolysin III family protein -
NV397_RS03975 (NV397_03975) 804270..805253 - 984 WP_163621823.1 tRNA-modifying protein YgfZ -
NV397_RS03980 (NV397_03980) 805499..805765 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NV397_RS03985 (NV397_03985) 805746..806156 + 411 WP_002916310.1 protein YgfX Toxin
NV397_RS03990 (NV397_03990) 806163..806684 - 522 WP_087638529.1 flavodoxin FldB -
NV397_RS03995 (NV397_03995) 806785..807681 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NV397_RS04000 (NV397_04000) 807704..808417 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NV397_RS04005 (NV397_04005) 808423..810156 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254264 WP_002916310.1 NZ_CP102841:805746-806156 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254264 WP_002916312.1 NZ_CP102841:805499-805765 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References