Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 10362..10942 Replicon plasmid pKP0079-4
Accession NZ_CP102840
Organism Klebsiella pneumoniae strain KP0079

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag NV396_RS29055 Protein ID WP_071177730.1
Coordinates 10628..10942 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag NV396_RS29050 Protein ID WP_000093040.1
Coordinates 10362..10640 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV396_RS29030 (NV396_29030) 6803..8290 - 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
NV396_RS29035 (NV396_29035) 8935..9180 + 246 WP_032440458.1 hypothetical protein -
NV396_RS29040 (NV396_29040) 9454..9825 + 372 WP_001237044.1 cell envelope integrity protein TolA -
NV396_RS29045 (NV396_29045) 9822..10187 + 366 WP_072354022.1 TonB family protein -
NV396_RS29050 (NV396_29050) 10362..10640 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
NV396_RS29055 (NV396_29055) 10628..10942 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV396_RS29060 (NV396_29060) 11106..11534 + 429 WP_001140599.1 hypothetical protein -
NV396_RS29065 (NV396_29065) 11560..11739 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
NV396_RS29070 (NV396_29070) 11766..12296 - 531 WP_071177729.1 hypothetical protein -
NV396_RS29075 (NV396_29075) 12303..13034 - 732 WP_071177728.1 MobC family replication-relaxation protein -
NV396_RS29080 (NV396_29080) 13034..14998 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..23940 23940


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T254261 WP_071177730.1 NZ_CP102840:10628-10942 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT254261 WP_000093040.1 NZ_CP102840:10362-10640 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References