Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5324304..5324929 Replicon chromosome
Accession NZ_CP102836
Organism Klebsiella pneumoniae strain KP0079

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag NV396_RS26210 Protein ID WP_002882817.1
Coordinates 5324304..5324687 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NV396_RS26215 Protein ID WP_004150355.1
Coordinates 5324687..5324929 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV396_RS26195 (NV396_26195) 5321670..5322572 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NV396_RS26200 (NV396_26200) 5322569..5323204 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NV396_RS26205 (NV396_26205) 5323201..5324130 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NV396_RS26210 (NV396_26210) 5324304..5324687 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
NV396_RS26215 (NV396_26215) 5324687..5324929 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NV396_RS26220 (NV396_26220) 5325134..5326051 + 918 WP_002882812.1 alpha/beta hydrolase -
NV396_RS26225 (NV396_26225) 5326065..5327006 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NV396_RS26230 (NV396_26230) 5327051..5327488 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NV396_RS26235 (NV396_26235) 5327485..5328345 - 861 WP_002882807.1 virulence factor BrkB family protein -
NV396_RS26240 (NV396_26240) 5328339..5328938 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T254250 WP_002882817.1 NZ_CP102836:c5324687-5324304 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT254250 WP_004150355.1 NZ_CP102836:c5324929-5324687 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References