Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4999052..5000733 Replicon chromosome
Accession NZ_CP102836
Organism Klebsiella pneumoniae strain KP0079

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NV396_RS24695 Protein ID WP_002885155.1
Coordinates 4999052..4999969 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NV396_RS24700 Protein ID WP_004151732.1
Coordinates 4999975..5000733 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV396_RS24675 (NV396_24675) 4994358..4995878 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NV396_RS24680 (NV396_24680) 4995875..4996873 + 999 WP_002885172.1 ribose ABC transporter permease -
NV396_RS24685 (NV396_24685) 4996904..4997845 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NV396_RS24690 (NV396_24690) 4997920..4998927 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NV396_RS24695 (NV396_24695) 4999052..4999969 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NV396_RS24700 (NV396_24700) 4999975..5000733 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NV396_RS24705 (NV396_24705) 5000819..5001547 - 729 WP_002885152.1 response regulator transcription factor -
NV396_RS24710 (NV396_24710) 5001820..5003967 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NV396_RS24715 (NV396_24715) 5004197..5004883 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T254249 WP_002885155.1 NZ_CP102836:c4999969-4999052 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT254249 WP_004151732.1 NZ_CP102836:c5000733-4999975 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References