Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4738246..4739056 Replicon chromosome
Accession NZ_CP102836
Organism Klebsiella pneumoniae strain KP0079

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag NV396_RS23390 Protein ID WP_002887280.1
Coordinates 4738246..4738779 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag NV396_RS23395 Protein ID WP_002887278.1
Coordinates 4738790..4739056 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV396_RS23385 (NV396_23385) 4737077..4738198 + 1122 WP_002887282.1 cupin domain-containing protein -
NV396_RS23390 (NV396_23390) 4738246..4738779 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
NV396_RS23395 (NV396_23395) 4738790..4739056 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NV396_RS23400 (NV396_23400) 4739159..4740592 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
NV396_RS23405 (NV396_23405) 4740582..4741265 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NV396_RS23410 (NV396_23410) 4741437..4742822 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
NV396_RS23415 (NV396_23415) 4742840..4743184 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T254247 WP_002887280.1 NZ_CP102836:c4738779-4738246 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT254247 WP_002887278.1 NZ_CP102836:c4739056-4738790 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References