Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4871211..4871727 Replicon chromosome
Accession NZ_CP102833
Organism Klebsiella pneumoniae strain KP4962

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NV394_RS23860 Protein ID WP_023317444.1
Coordinates 4871211..4871495 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NV394_RS23865 Protein ID WP_002886901.1
Coordinates 4871485..4871727 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV394_RS23835 (4866606) 4866606..4866869 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
NV394_RS23840 (4866999) 4866999..4867172 + 174 WP_032408826.1 hypothetical protein -
NV394_RS23845 (4867175) 4867175..4867918 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NV394_RS23850 (4868275) 4868275..4870413 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
NV394_RS23855 (4870743) 4870743..4871207 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NV394_RS23860 (4871211) 4871211..4871495 - 285 WP_023317444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV394_RS23865 (4871485) 4871485..4871727 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NV394_RS23870 (4871805) 4871805..4873715 - 1911 WP_004152270.1 PRD domain-containing protein -
NV394_RS23875 (4873738) 4873738..4874892 - 1155 WP_002886900.1 lactonase family protein -
NV394_RS23880 (4874959) 4874959..4875699 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11151.99 Da        Isoelectric Point: 10.3787

>T254232 WP_023317444.1 NZ_CP102833:c4871495-4871211 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT254232 WP_002886901.1 NZ_CP102833:c4871727-4871485 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References