Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2766147..2767735 Replicon chromosome
Accession NZ_CP102833
Organism Klebsiella pneumoniae strain KP4962

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NV394_RS13660 Protein ID WP_032436337.1
Coordinates 2766147..2767469 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NV394_RS13665 Protein ID WP_002904790.1
Coordinates 2767469..2767735 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV394_RS13645 (2761204) 2761204..2763705 + 2502 WP_032436339.1 fimbria/pilus outer membrane usher protein -
NV394_RS13650 (2763693) 2763693..2764697 + 1005 WP_032436338.1 fimbrial protein -
NV394_RS13655 (2764838) 2764838..2766130 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NV394_RS13660 (2766147) 2766147..2767469 - 1323 WP_032436337.1 type II toxin-antitoxin system HipA family toxin Toxin
NV394_RS13665 (2767469) 2767469..2767735 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NV394_RS13670 (2768122) 2768122..2768448 - 327 WP_032436336.1 hydroxyisourate hydrolase -
NV394_RS13675 (2768445) 2768445..2768945 - 501 WP_032436335.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NV394_RS13680 (2768923) 2768923..2770302 - 1380 Protein_2684 purine permease -
NV394_RS13685 (2770648) 2770648..2771802 + 1155 WP_150020106.1 FAD-dependent urate hydroxylase HpxO -
NV394_RS13690 (2771783) 2771783..2772706 - 924 WP_032436334.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49106.39 Da        Isoelectric Point: 7.5617

>T254229 WP_032436337.1 NZ_CP102833:c2767469-2766147 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGDHWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT254229 WP_002904790.1 NZ_CP102833:c2767735-2767469 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References