Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812849..813506 Replicon chromosome
Accession NZ_CP102833
Organism Klebsiella pneumoniae strain KP4962

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NV394_RS04025 Protein ID WP_002916310.1
Coordinates 813096..813506 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NV394_RS04020 Protein ID WP_002916312.1
Coordinates 812849..813115 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV394_RS03995 (808057) 808057..809490 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NV394_RS04000 (809609) 809609..810337 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NV394_RS04005 (810387) 810387..810698 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NV394_RS04010 (810862) 810862..811521 + 660 WP_002916317.1 hemolysin III family protein -
NV394_RS04015 (811620) 811620..812603 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
NV394_RS04020 (812849) 812849..813115 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NV394_RS04025 (813096) 813096..813506 + 411 WP_002916310.1 protein YgfX Toxin
NV394_RS04030 (813513) 813513..814034 - 522 WP_004144730.1 flavodoxin FldB -
NV394_RS04035 (814135) 814135..815031 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NV394_RS04040 (815054) 815054..815767 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NV394_RS04045 (815773) 815773..817506 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T254223 WP_002916310.1 NZ_CP102833:813096-813506 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT254223 WP_002916312.1 NZ_CP102833:812849-813115 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References