254220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 16390..16978 Replicon plasmid pAB3927
Accession NZ_CP102832
Organism Acinetobacter baumannii strain AB3927

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag NV385_RS19405 Protein ID WP_000438827.1
Coordinates 16390..16677 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag NV385_RS19410 Protein ID WP_001983304.1
Coordinates 16664..16978 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV385_RS19385 (NV385_19385) 12316..13485 + 1170 WP_002134206.1 MobA/MobL family protein -
NV385_RS19390 (NV385_19390) 14082..15017 + 936 WP_001292329.1 replication initiation protein RepM -
NV385_RS19395 (NV385_19395) 15095..15613 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
NV385_RS19400 (NV385_19400) 15823..16122 + 300 WP_000358348.1 hypothetical protein -
NV385_RS19405 (NV385_19405) 16390..16677 + 288 WP_000438827.1 BrnT family toxin Toxin
NV385_RS19410 (NV385_19410) 16664..16978 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
NV385_RS19415 (NV385_19415) 17106..19517 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
NV385_RS19420 (NV385_19420) 19822..20283 + 462 WP_000761346.1 DIP1984 family protein -
NV385_RS19425 (NV385_19425) 20609..20818 - 210 WP_000069474.1 hypothetical protein -
NV385_RS19430 (NV385_19430) 20811..21113 - 303 WP_001129974.1 XRE family transcriptional regulator -
NV385_RS19435 (NV385_19435) 21106..21462 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22388 22388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T254220 WP_000438827.1 NZ_CP102832:16390-16677 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT254220 WP_001983304.1 NZ_CP102832:16664-16978 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References