254218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5196..5784 Replicon plasmid pAB3927
Accession NZ_CP102832
Organism Acinetobacter baumannii strain AB3927

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag NV385_RS19340 Protein ID WP_000438827.1
Coordinates 5196..5483 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag NV385_RS19345 Protein ID WP_001983304.1
Coordinates 5470..5784 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV385_RS19320 (NV385_19320) 745..1680 - 936 WP_001292329.1 replication initiation protein RepM -
NV385_RS19325 (NV385_19325) 2277..3446 - 1170 WP_002134206.1 MobA/MobL family protein -
NV385_RS19330 (NV385_19330) 3751..4512 + 762 WP_000425105.1 hypothetical protein -
NV385_RS19335 (NV385_19335) 4629..4928 + 300 WP_000358348.1 hypothetical protein -
NV385_RS19340 (NV385_19340) 5196..5483 + 288 WP_000438827.1 BrnT family toxin Toxin
NV385_RS19345 (NV385_19345) 5470..5784 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
NV385_RS19350 (NV385_19350) 5912..8323 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
NV385_RS19355 (NV385_19355) 8628..9089 + 462 WP_000761346.1 DIP1984 family protein -
NV385_RS19360 (NV385_19360) 9415..9624 - 210 WP_000069474.1 hypothetical protein -
NV385_RS19365 (NV385_19365) 9617..9919 - 303 WP_001129974.1 XRE family transcriptional regulator -
NV385_RS19370 (NV385_19370) 9912..10268 - 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22388 22388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T254218 WP_000438827.1 NZ_CP102832:5196-5483 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT254218 WP_001983304.1 NZ_CP102832:5470-5784 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References