Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 135708..137331 Replicon plasmid pYUHAP5-1
Accession NZ_CP102828
Organism Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NV345_RS24140 Protein ID WP_000088046.1
Coordinates 135708..137033 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NV345_RS24145 Protein ID WP_024136327.1
Coordinates 137038..137331 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV345_RS24110 132374..132673 - 300 WP_001572440.1 hypothetical protein -
NV345_RS24115 132728..132964 - 237 Protein_144 type I restriction-modification system subunit M N-terminal domain-containing protein -
NV345_RS24120 133422..133847 - 426 WP_001043843.1 hypothetical protein -
NV345_RS24125 134101..134916 - 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
NV345_RS24130 134929..135339 - 411 WP_000985911.1 hypothetical protein -
NV345_RS24135 135441..135647 - 207 WP_000134171.1 hypothetical protein -
NV345_RS24140 135708..137033 - 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NV345_RS24145 137038..137331 - 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NV345_RS24150 137935..138327 - 393 WP_000341066.1 hypothetical protein -
NV345_RS24155 138700..139041 + 342 WP_001151575.1 hypothetical protein -
NV345_RS24160 139133..139324 + 192 WP_000398480.1 hypothetical protein -
NV345_RS24165 139374..139655 + 282 WP_000077926.1 hypothetical protein -
NV345_RS24170 139996..140127 - 132 WP_000374059.1 hypothetical protein -
NV345_RS24175 140218..141459 - 1242 WP_001053338.1 VWA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / aph(3')-IIa / armA / dfrA17 / aadA5 / oqxB / oqxA / blaCTX-M-65 / floR / sul2 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / tet(A) - 1..237848 237848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T254216 WP_000088046.1 NZ_CP102828:c137033-135708 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT254216 WP_024136327.1 NZ_CP102828:c137331-137038 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References