Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3935619..3936244 Replicon chromosome
Accession NZ_CP102827
Organism Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NV345_RS19085 Protein ID WP_000911337.1
Coordinates 3935619..3936017 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag NV345_RS19090 Protein ID WP_000557545.1
Coordinates 3936017..3936244 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV345_RS19070 (3932294) 3932294..3932881 - 588 WP_023227728.1 fimbrial protein -
NV345_RS19075 (3933600) 3933600..3934232 - 633 WP_023227727.1 YfdX family protein -
NV345_RS19080 (3934279) 3934279..3934815 - 537 WP_023227726.1 STM3031 family outer membrane protein -
NV345_RS19085 (3935619) 3935619..3936017 - 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NV345_RS19090 (3936017) 3936017..3936244 - 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
NV345_RS19095 (3936412) 3936412..3936672 + 261 WP_023227725.1 hypothetical protein -
NV345_RS19100 (3936947) 3936947..3937753 + 807 WP_010989071.1 DUF1460 domain-containing protein -
NV345_RS19110 (3938038) 3938038..3938796 - 759 WP_000244318.1 amidase activator ActS -
NV345_RS19115 (3939061) 3939061..3939606 + 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NV345_RS19120 (3939682) 3939682..3941199 - 1518 WP_000003339.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3927171..3937753 10582


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T254213 WP_000911337.1 NZ_CP102827:c3936017-3935619 [Salmonella enterica subsp. enterica serovar Indiana]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT254213 WP_000557545.1 NZ_CP102827:c3936244-3936017 [Salmonella enterica subsp. enterica serovar Indiana]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References