Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 3779450..3780264 | Replicon | chromosome |
| Accession | NZ_CP102827 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A4Y6MAM1 |
| Locus tag | NV345_RS18385 | Protein ID | WP_023227563.1 |
| Coordinates | 3779737..3780264 (+) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | A0A4Y6M833 |
| Locus tag | NV345_RS18380 | Protein ID | WP_072162154.1 |
| Coordinates | 3779450..3779740 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NV345_RS18350 (3775401) | 3775401..3776051 | - | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| NV345_RS18355 (3776507) | 3776507..3776950 | + | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| NV345_RS18360 (3777381) | 3777381..3777830 | + | 450 | WP_000381610.1 | membrane protein | - |
| NV345_RS18365 (3777815) | 3777815..3778162 | + | 348 | WP_001669174.1 | DUF1493 family protein | - |
| NV345_RS18370 (3778435) | 3778435..3778761 | - | 327 | WP_000393302.1 | hypothetical protein | - |
| NV345_RS18375 (3779002) | 3779002..3779180 | + | 179 | Protein_3573 | IS3 family transposase | - |
| NV345_RS18380 (3779450) | 3779450..3779740 | + | 291 | WP_072162154.1 | DUF1778 domain-containing protein | Antitoxin |
| NV345_RS18385 (3779737) | 3779737..3780264 | + | 528 | WP_023227563.1 | GNAT family N-acetyltransferase | Toxin |
| NV345_RS18390 (3780337) | 3780337..3780554 | - | 218 | Protein_3576 | IS5/IS1182 family transposase | - |
| NV345_RS18395 (3780889) | 3780889..3781545 | + | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| NV345_RS18400 (3781790) | 3781790..3782284 | - | 495 | WP_023227564.1 | hypothetical protein | - |
| NV345_RS18405 (3782311) | 3782311..3782979 | - | 669 | WP_000445914.1 | hypothetical protein | - |
| NV345_RS18410 (3783565) | 3783565..3783963 | - | 399 | Protein_3580 | cytoplasmic protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 3780337..3780477 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19099.93 Da Isoelectric Point: 9.6420
>T254212 WP_023227563.1 NZ_CP102827:3779737-3780264 [Salmonella enterica subsp. enterica serovar Indiana]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGSVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.54 Da Isoelectric Point: 8.5779
>AT254212 WP_072162154.1 NZ_CP102827:3779450-3779740 [Salmonella enterica subsp. enterica serovar Indiana]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Y6MAM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4Y6M833 |