254207

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2331807..2332329 Replicon chromosome
Accession NZ_CP102827
Organism Salmonella enterica subsp. enterica serovar Indiana strain XZ14C1328

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag NV345_RS11285 Protein ID WP_000221343.1
Coordinates 2331807..2332091 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NV345_RS11290 Protein ID WP_000885424.1
Coordinates 2332081..2332329 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV345_RS11260 (2326963) 2326963..2328204 - 1242 WP_023227499.1 MFS transporter -
NV345_RS11265 (2328194) 2328194..2329702 - 1509 WP_023227500.1 FAD-dependent oxidoreductase -
NV345_RS11270 (2329747) 2329747..2330235 + 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
NV345_RS11275 (2330428) 2330428..2331507 + 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NV345_RS11280 (2331559) 2331559..2331759 - 201 Protein_2185 Rid family hydrolase -
NV345_RS11285 (2331807) 2331807..2332091 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NV345_RS11290 (2332081) 2332081..2332329 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NV345_RS11295 (2332854) 2332854..2333186 + 333 WP_023227504.1 DUF1493 family protein -
NV345_RS11300 (2333337) 2333337..2334245 + 909 WP_077910000.1 hypothetical protein -
NV345_RS11305 (2334317) 2334317..2334604 - 288 WP_071787797.1 helix-turn-helix domain-containing protein -
NV345_RS11310 (2335068) 2335068..2335190 + 123 WP_254891910.1 hypothetical protein -
NV345_RS11315 (2335221) 2335221..2336687 - 1467 WP_023893409.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T254207 WP_000221343.1 NZ_CP102827:c2332091-2331807 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT254207 WP_000885424.1 NZ_CP102827:c2332329-2332081 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References